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Intraventricular pilocytic astrocytoma in an adult patient.

Authors
  • Hendrix, Joshua1
  • Xiong, Zhenggang1
  • 1 Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers University, NJ, USA.
Type
Published Article
Journal
Intractable & rare diseases research
Publication Date
Nov 01, 2020
Volume
9
Issue
4
Pages
260–262
Identifiers
DOI: 10.5582/irdr.2020.03088
PMID: 33139987
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Pilocytic astrocytomas are tumors of the central nervous system mostly during the first two decades of life. Although they are mostly common in the midline structures of children, pilocytic astrocytoma within the ventricular system of an adult is extremely rare. We report a case of a 38-year old woman with obstructive hydrocephalus secondary to a brain tumor within the third ventricle. On histological examination, the tumor exhibited biphasic growth pattern comprising compacted cellular areas with Rosenthal fibers and loose textured microcystic areas with eosinophilic granular bodies. Mitosis or necrosis was not present. Immunohistochemical studies demonstrated glial fibrillary acid protein (GFAP), Olig2, and ATRX positivity as well as NeuN and EMA negativity. Ki67 labeling index was less than 1%. Molecular studies revealed that there are no isocitrate dehydrogenase (IDH) gene mutation and H3F3A mutation. This clinical presentation along with the histologic and molecular findings is consistent with a pilocytic astrocytoma arising in the third ventricle of this adult brain, which indicates that pilocytic astrocytoma can present as an intraventricular tumor in an adult patient and should be routinely included in the differential diagnosis of intraventricular brain neoplasm. 2020, International Research and Cooperation Association for Bio & Socio - Sciences Advancement.

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