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Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats.

Authors
  • Suzuki, Syuuichirou
  • Kawamata, Jun
  • Iwahara, Naotoshi
  • Iwahara, Naoyuki
  • Matsumura, Akihiro
  • Hisahara, Shin
  • Matsushita, Takashi
  • Sasaki, Masanori
  • Honmou, Osamu
  • Shimohama, Shun
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Jan 01, 2015
Volume
584
Pages
276–281
Identifiers
DOI: 10.1016/j.neulet.2014.10.039
PMID: 25449872
Source
Medline
Keywords
License
Unknown

Abstract

To explore a novel therapy against Parkinson's disease (PD), we evaluated the therapeutic effects of human bone marrow-derived mesenchymal stem cells (hBM-MSCs), pluripotent stromal cells with secretory potential of various neurotrophic and anti-inflammatory factors, in a hemi-parkinsonian rat model. The unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were injected hBM-MSCs (1.0 × 10(7)cells) or PBS intravenously 16 days after lesioning. Administration of hBM-MSCs inhibited methamphetamine-stimulated rotational behavior at 7, 14, 21 and 28 days after transplantation. Immunohistochemical analysis also showed that number of TH-positive neurons in the substantia nigra pars compacta was significantly preserved in hBM-MSCs-transplanted rats compared to sham-operated rats, whereas the immunoreactivity of ionized calcium binding adaptor molecule 1 was markedly inhibited. In this study, we demonstrated the therapeutic effects of intravenous hBM-MSCs administration in parkinsonian model rats presenting distinct parkinsonian phenotype at 16 days after 6-OHDA lesioning. The favorable findings raise the possibility that hBM-MSCs could be a novel therapeutic option to promote survival of dopaminergic neurons in PD.

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