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Intravenous fibroblast growth factor penetrates the blood-brain barrier and protects hippocampal neurons against ischemia-reperfusion injury.

Authors
  • Cuevas, P
  • Carceller, F
  • Muñoz-Willery, I
  • Giménez-Gallego, G
Type
Published Article
Journal
Surgical Neurology
Publisher
Elsevier
Publication Date
Jan 01, 1998
Volume
49
Issue
1
Identifiers
PMID: 9428898
Source
Medline
License
Unknown

Abstract

We report that a venous injection of either native or nonmitogenic form of aFGF after 5 min forebrain ischemia in the gerbil significantly reduced the occurrence of delayed neuronal death (DND) in the CA1 sector of the hippocampus. We also confirmed that blood-borne 14C-bFGF accumulates in CA1 pyramidal neurons.

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