Affordable Access

Intravenous benztropine and propranolol challenges in acute neuroleptic-induced akathisia.

Authors
  • Sachdev, P
  • Loneragan, C
Type
Published Article
Journal
Clinical Neuropharmacology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Aug 01, 1993
Volume
16
Issue
4
Pages
324–331
Identifiers
PMID: 8104097
Source
Medline
License
Unknown

Abstract

We challenged six patients suffering from acute neuroleptic-induced akathisia (NIA) with intravenous benztropine (2 mg), propranolol (1 mg), and placebo (saline) using a random, double-blind cross-over design to examine the effects of the drugs on the subjective, objective, and global manifestations of NIA. Benztropine produced a significant amelioration of NIA, more apparent in its subjective component. Propranolol failed to produce a significant improvement overall in any of the akathisia measures, with only one patient showing clinical improvement. The patients demonstrated considerable placebo effect and marked variation in their responses to the drugs.

Report this publication

Statistics

Seen <100 times