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Intrathecal immune response in neonatal Flavobacterium meningosepticum meningitis.

Authors
  • Abrahamsen, T G
  • Mollnes, T E
  • Vandvik, B
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 1995
Volume
68
Issue
2
Pages
153–156
Identifiers
PMID: 8534775
Source
Medline
License
Unknown

Abstract

Neonates are predisposed to serious infections such as meningitis, probably due to their immature host reaction to the pathogens. We have studied the intrathecal immune response in 2 newborns with Flavobacterium meningosepticum meningitis. They showed a significant elevation of immunoglobulin indices ( >1.10), also after the CSF had become sterile with a normalized cell count. In addition, an intrathecal increase and subsequent decrease of both C3dg and TCC (terminal complement complex) were observed in 1 patient. We conclude that immunoglobulin production and complement activation may occur in neonatal CSF.

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