Intraperitoneal disease dissemination patterns are associated with residual disease, extent of surgery, and molecular subtypes in advanced ovarian cancer.

Diogo Torres; Amanika Kumar; Sumer K Wallace; Jamie N Bakkum-Gamez; Gottfried E Konecny; Amy L Weaver; Michaela E McGree; Ellen L Goode; William A Cliby; Chen Wang

doi:10.1016/j.ygyno.2017.09.021

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Intraperitoneal disease dissemination patterns are associated with residual disease, extent of surgery, and molecular subtypes in advanced ovarian cancer.

Authors

Torres, Diogo¹
Kumar, Amanika¹
Wallace, Sumer K¹
Bakkum-Gamez, Jamie N¹
Konecny, Gottfried E²
Weaver, Amy L³
McGree, Michaela E³
Goode, Ellen L⁴
Cliby, William A¹
Wang, Chen⁵

¹ Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States. , (United States)
² Department of Medicine, Division of Hematology/Oncology, University of California Los Angeles, Los Angeles, CA, United States. , (United States)
³ Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States. , (United States)
⁴ Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, United States. , (United States)
⁵ Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States; Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States. Electronic address: [email protected] , (United States)

Type

Published Article

Journal

Gynecologic Oncology

Publisher

Elsevier

Publication Date

Dec 01, 2017

Volume

147

Issue

3

Pages

503–508

Identifiers

DOI: 10.1016/j.ygyno.2017.09.021

PMID: 28964622

Source

Medline

License

Unknown

Abstract

IP disease dissemination patterns are associated with RD, surgical complexity, and tumor molecular subtypes. Patients with upper abdominal or miliary dissemination patterns are more likely to have mesenchymal HGSOC and in turn achieve lower rates of complete resection. This provides a plausible model for how the biologic behavior of molecular subtypes is manifest in disease and oncologic outcomes.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 06/09/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/28964622

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