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Intraosseous schwannoma in schwannomatosis.

Authors
  • Kashima, T G
  • Gibbons, M R J P
  • Whitwell, D
  • Gibbons, C L M H
  • Bradley, K M
  • Ostlere, S J
  • Athanasou, N A
Type
Published Article
Journal
Skeletal Radiology
Publisher
Springer-Verlag
Publication Date
Dec 01, 2013
Volume
42
Issue
12
Pages
1665–1671
Identifiers
DOI: 10.1007/s00256-013-1712-6
PMID: 23995262
Source
Medline
License
Unknown

Abstract

This study investigates the clinical, radiological, and pathological features of two cases of intraosseous schwannoma that arose in patients with multiple soft tissue schwannomas. In both cases, the patients were adult females and the tibial bone was affected. Vestibular schwannomas were not identified, indicating that these were not cases of neurofibromatosis 2 (NF2). Radiographs showed a well-defined lytic lesion in the proximal tibia; in one case, this was associated with a pathological fracture. Histologically, both cases showed typical features of benign schwannoma. Molecular analysis of one of the excised tumors showed different alterations in the NF2 gene in keeping with a diagnosis of schwannomatosis. Our findings show for the first time that intraosseous schwannomas can occur in schwannomatosis.

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