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Intraoperative orthovoltage radiation therapy in the treatment of recurrent gynecologic malignancies.

Authors
  • Hicks, M L
  • Piver, M S
  • Mas, E
  • Hempling, R E
  • Mcauley, M
  • Walsh, D L
Type
Published Article
Journal
American Journal of Clinical Oncology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 01, 1993
Volume
16
Issue
6
Pages
497–500
Identifiers
PMID: 8256765
Source
Medline
License
Unknown

Abstract

A Phase I/II study was initiated to evaluate complications of orthovoltage intraoperative radiation therapy utilized in the treatment of patients with incompletely resected recurrent gynecologic malignancies. There were no osseous, vascular, neurologic, or ureteral complications. Of the 23 treated patients, 2 patients (8.7%) had complications outside the treated area. Survival of patients treated with intraoperative radiation therapy was highest among patients treated to a field of < or = 3 cm in greatest diameter and a tumor thickness of < or = 1 mm. A subgroup of patients (5) with microscopically positive margins following total pelvic exenteration demonstrated an absence of recurrence in the treated field. The role of intraoperative radiation therapy (IORT) in the treatment of recurrent and incompletely resectable gynecologic malignancies remains investigational.

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