The left eye of a 43-year-old patients was removed 37 years after a perforating injury because of a painful absolute secondary closed-angle glaucoma. Histological investigation revealed a massive reactive gliosis of the retina filling the entire eye. Glial fibrillary acidic protein was demonstrated within this pseudotumor by means of an immunoperoxidase. Clinical and histopathological differential diagnoses are discussed. The diagnostic value of immunohistochemical demonstration of glial fibrillary acidic protein is pointed out.