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Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B.

Authors
  • Chen, Ji
  • Wang, Xiao-Mei
  • Wu, Xue-Jie
  • Wang, Yan
  • Zhao, Hong
  • Shen, Bing
  • Wang, Gui-Qiang
Type
Published Article
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Publication Date
Jan 01, 2011
Volume
60
Issue
1
Pages
47–53
Identifiers
DOI: 10.1007/s00011-010-0233-1
PMID: 20661763
Source
Medline
License
Unknown

Abstract

These results suggest that over-expression of PD-1, PD-L1 and PD-L2 within liver may participate in local immune dysfunction, which could be one of the mechanisms involved in the chronicity of HBV infection and chronic inflammation seen in CHB patients.

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