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Intrahepatic cholangiocarcinoma is more complex than we thought: A case report

Authors
  • Zeng, Jian-Ting
  • Zhang, Jie-Feng
  • Wang, Yu
  • Qing, Zhou
  • Luo, Zhen-Hua
  • Zhang, Yan-Lin
  • Zhang, Yi
  • Luo, Xian-Zhang
Type
Published Article
Journal
World Journal of Clinical Cases
Publisher
Baishideng Publishing Group Inc
Publication Date
Feb 26, 2021
Volume
9
Issue
6
Pages
1469–1474
Identifiers
DOI: 10.12998/wjcc.v9.i6.1469
PMID: 33644217
PMCID: PMC7896692
Source
PubMed Central
Keywords
Disciplines
  • Case Report
License
Green

Abstract

BACKGROUND Brain metastasis from intrahepatic cholangiocarcinoma is rare. To the best of our knowledge, only a few cases have been reported. The biological behavior was complex, and treatment requires further investigation. CASE SUMMARY A 62-year-old woman complained of left limb weakness. Abdominal computed tomography showed a 5.0 cm × 5.6 cm lesion in the left lobe of the liver. Tumor markers were normal. Serological analysis indicated absence of hepatitis virus. Brain magnetic resonance imaging revealed a 1.0 cm × 1.3 cm mass in the right frontal lobe. Intrahepatic cholangiocarcinoma with brain metastasis was diagnosed by our liver cancer multidisciplinary team. After sufficient preparation, the patient underwent partial frontal lobotomy and left hemihepatectomy. Histopathological results confirmed that both the lesions were cholangiocarcinoma. Six cycles of gemcitabine combined with S1 were administered. During a 39 mo postoperative follow-up, no sign of local recurrence or distant metastasis was observed. CONCLUSION This case expands our knowledge concerning the complex and heterogeneous nature of tumor metastasis.

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