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Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery

Authors
  • Yamamoto, Takuya1
  • Abe, Tomoyuki2
  • Oshita, Akihiko2, 3
  • Yonehara, Shuji1
  • Katamura, Yoshio1
  • Matsumoto, Nozomu1
  • Kobayashi, Tsuyoshi3
  • Nakahara, Masahiro2
  • Ohdan, Hideki3
  • Noriyuki, Toshio2, 3
  • 1 Onomichi General Hospital, Onomichi, Hiroshima, Japan , Onomichi (Japan)
  • 2 Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, Hiroshima, 722-8508, Japan , Onomichi (Japan)
  • 3 Hiroshima University, Hiroshima, Japan , Hiroshima (Japan)
Type
Published Article
Journal
Surgical Case Reports
Publisher
Springer Berlin Heidelberg
Publication Date
Oct 07, 2020
Volume
6
Issue
1
Identifiers
DOI: 10.1186/s40792-020-01041-2
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundIntrahepatic cholangiocarcinoma (ICC) is the second most common malignancy of primary liver cancer. Among the several pathological types of ICC, only five cases of the clear cell type have been reported, including the one presented below. Here we report a unique case of clear cell type ICC following laparoscopic hepatectomy.Case presentationA 67-year-old woman had a history of hepatitis B virus. Computed tomography revealed a ring-like enhanced mass 35 mm in diameter at segment 7 in the early phase. The enhancement was prolonged to the late phase through the portal phase, while the shape was irregular. Ethoxybenzy magnetic resonance imaging revealed that the tumor had a low signal intensity on T1-weighted imaging and a high signal intensity on T2-weighted imaging. Diffusion-weighted images identified that the tumor had remarkably high signal intensity. Tumor enhancement was not detected throughout the tumor in the hepatocyte phase. Upon ICC diagnosis, a laparoscopic S7 subsegmentectomy was performed. The patient’s postoperative course was uneventful. An immunohistochemical examination revealed that the cells tested positive for cytokeratin 7 (CK7), CK19, and CD56 and negative for CK20, CD10, α-fetoprotein, thyroid transcription factor-1. At 2 years after surgery, the patient remains alive without recurrence.ConclusionsHere we presented a case of clear cell ICC that was treated by laparoscopic hepatectomy. Immunological analysis, especially by CD56 and several CK markers, is helpful for diagnosing this disease.

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