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[Intracranial pressure. II. Experimental verification of a mathematical model].

Authors
  • Benabid, A L
  • de Rougemont, J
  • Barge, M
Type
Published Article
Journal
Journal de physiologie
Publication Date
May 01, 1975
Volume
70
Issue
1
Pages
41–59
Identifiers
PMID: 1177157
Source
Medline
License
Unknown

Abstract

The authors report the results of experiments (performed on the dog in vitro and in vivo) which were designed to verify hypotheses made concerning vascular elasticity and characteristics of CSF resorption, as well as to test the validity of a mathematical model that was described in a previous paper. The authors concluded that the equations of the model account for most of the phenomena satisfactorily, but fail to predict a rebound phenomena which occurs after sudden injections in the cisterna magna. The elasticity coefficient S appears to be constant over a range of 200 mm Hg. On the other hand, the filtration coefficient K depends upon pressure, probably due to morphological changes in the size and shape of the CSF valves. These discrepancies are taken into account in a more general model that is presented in the following paper.

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