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Intracerebral Hemorrhage and Outcome After Thrombolysis in Stroke Patients Using Selective Serotonin-Reuptake Inhibitors.

Authors
  • Scheitz, Jan F1
  • Turc, Guillaume2
  • Kujala, Linda2
  • Polymeris, Alexandros A2
  • Heldner, Mirjam R2
  • Zonneveld, Thomas P2
  • Erdur, Hebun2
  • Curtze, Sami2
  • Traenka, Christopher2
  • Brenière, Céline2
  • Wiest, Roland2
  • Rocco, Andrea2
  • Sibolt, Gerli2
  • Gensicke, Henrik2
  • Endres, Matthias2
  • Martinez-Majander, Nicolas2
  • Béjot, Yannick2
  • Nederkoorn, Paul J2
  • Oppenheim, Catherine2
  • Arnold, Marcel2
  • And 3 more
  • 1 From the Center for Stroke Research Berlin (J.F.S., G.T., M.E., C.H.N.), Klinik für Neurologie, Campus Benjamin Franklin (J.F.S., H.E., A.R., M.E., C.H.N.), DZHK (German Centre for Cardiovascular Research), partner site Berlin (J.F.S., M.E.), and German Center for Neurodegenerative Diseases (M.E.), Charité-Universitätsmedizin Berlin, Germany; Berlin Institute of Health, Germany (J.F.S., H.E., M.E.); Department of Neurology (G.T.) and Department of Neuroradiology (C.O.) Hôpital Sainte Anne, Université Sorbonne Paris Cité, France; INSERM U894, Paris, France (G.T., C.O.); Department of Neurology, Helsinki University Hospital, Finland (L.K., S.C., G.S., N.M.-M., D.S.); Stroke Center and Department of Neurology, University Hospital of Basel (A.A.P., C.T., H.G., S.T.E.) and Neurorehabilitation Unit, University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital (H.G., S.T.E.), University of Basel, Switzerland; Department of Neurology (M.R.H., M.A.) and Institute of Diagnostic and Interventional Neuroradiology (R.W.), University Hospital of Bern, University of Bern, Switzerland; Department of Neurology, Neurovascular Research Group, Academic Medical Center, Amsterdam, the Netherlands (T.P.Z., P.J.N.); and Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France (C.B., Y.B.). [email protected] , (Switzerland)
  • 2 From the Center for Stroke Research Berlin (J.F.S., G.T., M.E., C.H.N.), Klinik für Neurologie, Campus Benjamin Franklin (J.F.S., H.E., A.R., M.E., C.H.N.), DZHK (German Centre for Cardiovascular Research), partner site Berlin (J.F.S., M.E.), and German Center for Neurodegenerative Diseases (M.E.), Charité-Universitätsmedizin Berlin, Germany; Berlin Institute of Health, Germany (J.F.S., H.E., M.E.); Department of Neurology (G.T.) and Department of Neuroradiology (C.O.) Hôpital Sainte Anne, Université Sorbonne Paris Cité, France; INSERM U894, Paris, France (G.T., C.O.); Department of Neurology, Helsinki University Hospital, Finland (L.K., S.C., G.S., N.M.-M., D.S.); Stroke Center and Department of Neurology, University Hospital of Basel (A.A.P., C.T., H.G., S.T.E.) and Neurorehabilitation Unit, University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital (H.G., S.T.E.), University of Basel, Switzerland; Department of Neurology (M.R.H., M.A.) and Institute of Diagnostic and Interventional Neuroradiology (R.W.), University Hospital of Bern, University of Bern, Switzerland; Department of Neurology, Neurovascular Research Group, Academic Medical Center, Amsterdam, the Netherlands (T.P.Z., P.J.N.); and Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France (C.B., Y.B.). , (Switzerland)
Type
Published Article
Journal
Stroke
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Dec 01, 2017
Volume
48
Issue
12
Pages
3239–3244
Identifiers
DOI: 10.1161/STROKEAHA.117.018377
PMID: 29127269
Source
Medline
Keywords
License
Unknown

Abstract

Preadmission treatment with SSRIs was not significantly associated with an increased risk of post-thrombolysis sICH in this cohort study. However, subgroup analysis suggested an increased risk of sICH in patients taking both SSRI and OAC. Preadmission treatment with SSRIs was associated with unfavorable outcome, which may reflect the prognostic significance of prestroke depression.

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