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Intracellular potassium and chloride channels: an update.

Authors
Type
Published Article
Journal
Acta biochimica Polonica
Publication Date
Volume
48
Issue
1
Pages
137–144
Identifiers
PMID: 11440163
Source
Medline
License
Unknown

Abstract

Channels selective for potassium or chloride ions are present in all intracellular membranes such as mitochondrial membranes, sarcoplasmic/endoplasmic reticulum, nuclear membrane and chromaffin granule membranes. They probably play an important role in events such as acidification of intracellular compartments and regulation of organelle volume. Additionally, intracellular ion channels are targets for pharmacologically active compounds, e.g. mitochondrial potassium channels interact with potassium channel openers such as diazoxide. This review describes current observations concerning the properties and functional roles of intracellular potassium and chloride channels.

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