Affordable Access

Intracellular mechanisms in the activation of human platelets by low-density lipoproteins.

Authors
  • Andrews, H E
  • Aitken, J W
  • Hassall, D G
  • Skinner, V O
  • Bruckdorfer, K R
Type
Published Article
Journal
The Biochemical journal
Publication Date
Mar 01, 1987
Volume
242
Issue
2
Pages
559–564
Identifiers
PMID: 3109394
Source
Medline
License
Unknown

Abstract

Low-density lipoproteins (LDL) have been shown to cause aggregation of human blood platelets at concentrations above 2 g of protein/l. The secretion of the contents of platelet dense granules was detected, but not that of the lysosomes. LDL gave rise to a mobilization of [3H]arachidonic acid from phospholipids and the appearance of products of the cyclo-oxygenase pathway after only 10 s. LDL-promoted aggregation was inhibited by both aspirin and indomethacin. There was an increase in 3H-labelled diacylglycerols and the phosphorylation of 47 kDa proteins. LDL therefore shares at least some of the mechanisms of stimulus/response coupling with those of other agonists.

Report this publication

Statistics

Seen <100 times