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Intracellular Chloride Ion Channel Protein-1 Expression in Clear Cell Renal Cell Carcinoma.

Authors
  • Nesiu, Alexandru1
  • Cimpean, Anca Maria2, 3
  • Ceausu, Raluca Amalia4, 3
  • Adile, Ahmed1
  • Ioiart, Ioan1
  • Porta, Camillo5
  • Mazzanti, Michele6
  • Camerota, Tommaso Ciro7
  • Raica, Marius4, 3
  • 1 Department of Urology, Vasile Goldis University, Arad, Romania. , (Oman)
  • 2 Department of Microscopic Morphology/Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania [email protected] , (Oman)
  • 3 Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania. , (Oman)
  • 4 Department of Microscopic Morphology/Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania. , (Oman)
  • 5 Department of Internal Medicine, University of Pavia & Division of Translational Oncology, IRCCS ICS Maugeri of Pavia, Pavia, Italy. , (Italy)
  • 6 Department of Biosciences, Laboratory of Cellular and Molecular Physiology, University of Milano, Milan, Italy. , (Italy)
  • 7 Urology, IRCCS ICS Maugeri of Pavia, Pavia, Italy. , (Italy)
Type
Published Article
Journal
Cancer Genomics & Proteomics
Publisher
International Institute of Anticancer Research
Publication Date
Jan 01, 2019
Volume
16
Issue
4
Pages
299–307
Identifiers
DOI: 10.21873/cgp.20135
PMID: 31243111
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chloride intracellular channel 1 (CLIC1) represents a promising target for personalized therapy. Our aim was to assess CLIC1 expression in clear cell renal cell carcinoma (cc RCC) and identify its possible prognostic role. Fifty cases of cc RCC were evaluated and selected for immunohistochemistry. CLIC1 expression was correlated with tumor grade, invasion and heterogeneity. A total of 87.5% of the cases were CLIC1 positive, with either a homogeneous (31.42%) or a heterogeneous (68.57%) pattern. Low, mild and strong CLIC1 expressing tumors were defined based on nuclear (N), cytoplasmic (C), membrane (M) or combinations of them (NC, NM, CM, NCM) in terms of CLIC1 distribution. A significant correlation was found between tumor grade and percent of positive tumor cells (p=0.017). For G3 tumors, CLIC1 cytoplasmic expression was strongly correlated with high expression status (p=0.025) and tumor heterogeneity (p=0.004). CLIC1 expression was also correlated with metastasis (p=0.046). We defined four cc RCC groups depending on G, CLIC1 expression and pattern: i) G3/NM/low CLIC1+, ii) G2/CM/mild CLIC1+ iii) G1 or G2/NM or CM /high CLIC1+, and iv) G2/M /high CLIC1. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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