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Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels.

Authors
  • af Klint, Erik
  • Grundtman, Cecilia
  • Engström, Marianne
  • Catrina, Anca Irinel
  • Makrygiannakis, Dimitrios
  • Klareskog, Lars
  • Andersson, Ulf
  • Ulfgren, Ann-Kristin
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Dec 01, 2005
Volume
52
Issue
12
Pages
3880–3889
Identifiers
PMID: 16320336
Source
Medline
License
Unknown

Abstract

Synovial cell infiltration and proinflammatory cytokine expression were affected in a multifaceted manner by IA GC treatment. Marked reduction of synovial T lymphocytes, TNF, IL-1beta, extranuclear HMGB-1, ICAM-1, and VEGF occurred in association with beneficial clinical effects. Unexpectedly, macrophage infiltration and proinflammatory endothelial cytokine expression remained unchanged. These findings may reflect mechanisms controlling the transiency of clinical improvement frequently observed after IA GC injection.

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