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Intraarticular corticosteroid for treatment of osteoarthritis of the knee.

Authors
  • Bellamy, N1
  • Campbell, J
  • Robinson, V
  • Gee, T
  • Bourne, R
  • Wells, G
  • 1 University of Queensland, Centre Of National Research On Disability And Rehabilitation Medicine, Level 3, Mayne Medical School, Herston Road, Brisbane, Queensland, Australia, 4006. [email protected]
Type
Published Article
Journal
The Cochrane database of systematic reviews
Publication Date
Apr 19, 2006
Issue
2
Identifiers
PMID: 16625636
Source
Medline
License
Unknown

Abstract

The short-term benefit of IA corticosteroids in treatment of knee OA is well established, and few side effects have been reported. Longer term benefits have not been confirmed based on the RevMan analysis. The response to HA products appears more durable. In this review, some discrepancies were observed between the RevMan 4.2 analysis and the original publication. These are likely the result of using secondary rather than primary data and the statistical methods available in RevMan 4.2. Future trials should have standardised outcome measures and assessment times, run longer, investigate different patient subgroups, and clinical predictors of response (those associated with inflammation and structural damage).

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