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Intraamniotic infection due to group G streptococcus: treatment and antibody response.

Authors
  • Larsen, J W Jr
  • London, W T
  • Baker, C J
  • Curfman, B L
  • Sever, J L
Type
Published Article
Journal
Obstetrics and Gynecology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Aug 01, 1981
Volume
58
Issue
2
Pages
222–226
Identifiers
PMID: 7019795
Source
Medline
License
Unknown

Abstract

Penicillin treatment and antibody response were studied using a rhesus monkey model for intraamniotic infection with type III group B streptococci (T3GBS). Acute and convalescent phase sera from mothers and their offspring were tested with a radioactive antigen-binding assay to determine the concentration of antibody to the capsular T3GBS antigen. The frequency of placentitis was significantly lower in penicillin-treated animals (3 of 8) than in controls (10 of 10; P less than .01). The penicillin group also had a significantly lower neonatal mortality (1 of 9) than controls (6 of 10; P less than .05). Both groups of rhesus mothers developed a significant increase in concentration of antibody to T3GBS, but the antibody response was of lesser magnitude in the penicillin-treated group. This experimental model appears to be useful for studying both therapy for intraamniotic infection and the humoral immune response to infection with T3GBS.

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