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Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats.

Authors
  • Rubin, M A
  • Stiegemeier, J A
  • Volkweis, M A
  • Oliveira, D M
  • Fenili, A C
  • Boemo, R L
  • Jurach, A
  • Mello, C F
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Jun 29, 2001
Volume
423
Issue
1
Pages
35–39
Identifiers
PMID: 11438304
Source
Medline
License
Unknown

Abstract

In the present study, we investigated the effect of immediate post-training bilateral infusion of spermidine, a polyamine agonist, into the amygdala on inhibitory avoidance learning of rats. Bilateral microinjection of spermidine (0.02--20 nmol) caused an increase in test step-down latencies at high concentrations. Administration of arcaine (0.002--0.2 nmol), an antagonist of the NMDA receptor polyamine binding site, decreased test step-down latencies. On the other hand, co-administration of arcaine and spermidine completely reversed the spermidine-induced increase of test step-down latencies. These results provide evidence that polyamines may be involved in learning and memory modulation in the amygdala.

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