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Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells

Authors
  • Stakenborg, Nathalie
  • Viola, Maria F.
  • Boeckxstaens, Guy E.
Type
Published Article
Journal
Current Opinion in Neurobiology
Publisher
Current Biology
Publication Date
Jun 01, 2020
Volume
62
Pages
68–75
Identifiers
DOI: 10.1016/j.conb.2019.11.020
PMID: 31862627
PMCID: PMC7294228
Source
PubMed Central
Disciplines
  • Article
License
Unknown

Abstract

Intestinal homeostasis relies on the reciprocal crosstalk between enteric neurons and immune cells, which together form neuro-immune units that occupy distinct anatomical niches within the gut. Here we will review the recent advances in our understanding of neuro-immune crosstalk within the gut, with focus on macrophages, mast cells and innate lymphoid cells. In particular, we will discuss the role of neuron-immune cell crosstalk in homeostasis, and how aberrant communication may underlie disease in the gastro-intestinal tract.

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