Affordable Access

deepdyve-link
Publisher Website

Intestinal IFN-γ production is associated with protection from clinical signs, but not with elimination of worms, in Echinostoma caproni infected-mice.

Authors
  • Cortes, Alba
  • Sotillo, Javier
  • Muñoz-Antoli, Carla
  • Fried, Bernard
  • Esteban, J-Guillermo
  • Toledo, Rafael
Type
Published Article
Journal
Parasitology Research
Publisher
Springer-Verlag
Publication Date
Jun 01, 2014
Volume
113
Issue
6
Pages
2037–2045
Identifiers
DOI: 10.1007/s00436-014-3851-7
PMID: 24633907
Source
Medline
License
Unknown

Abstract

In the present paper, we assess the relationship between the expression of IFN-γ and the development of clinical signs in Echinostoma caproni-infected mice. For this purpose, we studied the course of the infection in three mouse strains: ICR (CD-1®) (a host of high compatibility with E. caproni), BALB/c (a prototypical Th2 strain), and BALB/c deficient for IFN-γ mice (IFN-γ(-/-)). Infection in ICR mice is characterized by the elevated expression of IFN-γ and iNOS in the intestine concomitantly with the lack of clinical signs. In contrast, the infection was more virulent in BALB/c and IFN-γ-deficient mice that developed a severe form of the disease together with the absence of IFN-γ expression. The disease was more severe in IFNγ(-/-) mice in which the disease was lethal during the few first weeks of the infection. The analysis of different parameters of the infection in each host strain showed that most of the features were similar in the three mouse strains, suggesting the IFN-γ plays a central role in that protection against severe disease. Thus, IFN-γ seems to play a dichotomous role in the infection facilitating the parasite establishment, but it may also benefit mice since it protects the mice from morbidity and mortality induced by the parasite.

Report this publication

Statistics

Seen <100 times