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Intestinal deconjugation of bilirubin in germfree and conventional rats.

Authors
  • Saxerholt, H
  • Midtvedt, T
Type
Published Article
Journal
Scandinavian journal of clinical and laboratory investigation
Publication Date
Jun 01, 1986
Volume
46
Issue
4
Pages
341–344
Identifiers
PMID: 3726443
Source
Medline
License
Unknown

Abstract

The content of conjugated bilirubin (CB) was about the same in small intestinal contents from germfree (GF) and conventional (CONV) rats. Caecal contents from GF rats contained considerably more CB than from CONV rats. The results indicated that the caecum is the major site of microbial deconjugation of CB in the CONV rat. Separation of azopigments prepared from small intestinal contents of GF and CONV rats revealed similar patterns. Similar separation patterns were also observed with azopigments prepared from caecal contents and faeces of GF rats. Some chemical properties of CB prepared from GF rat faeces were studied.

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