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Intestinal Adaptations after Bariatric Surgery: Consequences on Glucose Homeostasis

Authors
Type
Published Article
Journal
Trends in Endocrinology and Metabolism
Publisher
Elsevier
Publication Date
May 19, 2017
Volume
28
Issue
5
Pages
354–364
Identifiers
DOI: 10.1016/j.tem.2017.01.002
PMID: 28209316
OAI: oai:HAL:inserm-01480079v1
Source
USPC - SET - SVS
Keywords
License
Green
External links

Abstract

The gastrointestinal (GI) tract can play a direct role in glucose homeostasis by modulating the digestion and absorption of carbohydrates and by producing the incretin hormones. In recent years, numerous studies have focused on intestinal adaptation following bariatric surgeries. Changes in the number of incretin- (GLP-1, GIP) producing cells have been reported which could result in the modified hormonal response seen after surgery. Additionally, the rate of absorption and the intestinal regions exposed to sugars may affect the time course of appearance of glucose in the blood. This review gives new insights into the direct role of the GI tract in the metabolic outcomes of bariatric surgery, in the context of glucose homeostasis.

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