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Intervention to promote patients' adherence to antimalarial medication: a systematic review.

Authors
  • Fuangchan, Anjana
  • Dhippayom, Teerapon
  • Kongkaew, Chuenjid
Type
Published Article
Journal
American Journal of Tropical Medicine and Hygiene
Publisher
American Society of Tropical Medicine and Hygiene
Publication Date
Jan 01, 2014
Volume
90
Issue
1
Pages
11–19
Identifiers
DOI: 10.4269/ajtmh.12-0598
PMID: 24166045
Source
Medline
License
Unknown

Abstract

Non-adherence as a major contributor to poor treatment outcomes. This study aimed to explore the effectiveness of existing interventions promoting adherence to antimalarial drugs by systematic review. The following databases were used to identify potential articles: MEDLINE, EMBASE, the Cochrane CENTRAL, and CINAHL (through March 2013). From 1,813 potential papers identified, 16 studies met the selection criteria comprising 9,247 patients. Interventions were classified as packaging aids, visual media, combined visual media and verbal information, community education, medication supervision, and convenient regimen. These interventions were shown to increase adherence to antimalarial drugs (median relative risk = 1.4, interquartile range 1.2-2.0). Although a most effective intervention did not emerge, community education and visual media/verbal information combinations may well have most potential to improve adherence to antimalarial medication. These interventions should be implemented in combination to optimize their beneficial effects. The current understanding on improved adherence would facilitate to contain outbreaks of malaria cost effectively.

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