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Interspike Intervals Reveal Functionally Distinct Cell Populations in the Medial Entorhinal Cortex.

Authors
  • Latuske, Patrick
  • Toader, Oana
  • Allen, Kevin
Type
Published Article
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Publication Date
Aug 05, 2015
Volume
35
Issue
31
Pages
10963–10976
Identifiers
DOI: 10.1523/JNEUROSCI.0276-15.2015
PMID: 26245960
Source
Medline
Keywords
License
Unknown

Abstract

We report that neurons in the superficial layers of the medial entorhinal cortex can be classified based on their tendency to fire bursts of action potentials at 125-250 Hz. The relevance of this classification is demonstrated by the types of spatial information preferentially encoded by bursty and non-bursty neurons. Grid-like spatial periodicity is more commonly observed in bursty neurons, whereas most cells with head-direction selectivity or those that are firing at the border of the environment are non-bursty neurons. This work indicates that the spatial firing patterns of neurons in the medial entorhinal cortex can be predicted by electrophysiological features reflecting the synaptic inputs and/or integrating properties of the neurons.

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