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Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly

Authors
  • Haas, Alexis J.1
  • Zihni, Ceniz1
  • Ruppel, Artur2
  • Hartmann, Christian3
  • Ebnet, Klaus3
  • Tada, Masazumi4
  • Balda, Maria S.1
  • Matter, Karl1
  • 1 UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK
  • 2 LiPhy, CNRS, Université Grenoble Alpes, Grenoble 38000, France
  • 3 Institute-associated Research Group “Cell adhesion and cell polarity,” Institute of Medical Biochemistry, ZMBE, University of Münster, Münster 48149, Germany
  • 4 Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 21, 2020
Volume
32
Issue
3
Identifiers
DOI: 10.1016/j.celrep.2020.107924
PMID: 32697990
PMCID: PMC7383227
Source
PubMed Central
Keywords
License
Unknown

Abstract

Haas et al. reveal that mechanical forces acting on tight junctions are regulated by extracellular matrix properties and a cell-cell adhesion molecule. The adhesion protein regulates the activation of a junctional actomyosin regulatory mechanism that is required for tight junction assembly when forces acting on the junction are high.

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