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The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis

Authors
  • Charostad, J.1, 2
  • Nakhaie, M.1, 3
  • Dehghani, A.1
  • Faghihloo, E.4
  • 1 Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Ahvaz (Iran)
  • 2 Shahid Sadoghi University of Medical Science, Yazd, Iran , Yazd (Iran)
  • 3 Kerman University of Medical Sciences, Kerman, Iran , Kerman (Iran)
  • 4 Shahid Beheshti University of Medical Sciences, Tehran, Iran , Tehran (Iran)
Type
Published Article
Journal
Infectious Agents and Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 15, 2020
Volume
15
Issue
1
Identifiers
DOI: 10.1186/s13027-020-00317-4
Source
Springer Nature
Keywords
License
Green

Abstract

Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role in oncogenesis because of its function as a master regulator of a spectrum of genes involved in physiological and pathophysiological process. Constitutive activation of NF-κB is a frequent and well-described event in many human malignancies. Compelling evidence represent EBV and KSHV are capable of targeting different components of NF-κB cascade. Here, we summarized recent findings to clarify the precise relationship between dysregulation of NF-κB and EBV and KSHV-related malignancies. This essay also emphasizes on contribution of various viral products in developing cancer through alteration of NF-κB signaling pathway.

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