Intermolecular zero-quantum coherences (iZQCs) originating from distant dipolar interactions between spins in different molecules provide an innovative way for nuclear magnetic resonance (NMR) spectroscopy. Since the field experienced by iZQC signals is in the dipolar correlation distance, it is naturally to apply iZQCs for resolution enhancement in NMR spectroscopy, especially under the spatially and/or temporally varying magnetic fields. Two theoretical frames, classical distant dipolar field and quantum-mechanical intermolecular multiple-quantum coherence treatments, are available for the description of iZQC signal evolution. A variety of iZQC spectroscopic techniques have been established and most of them take advantage of two-dimensional acquisition to recover a one-dimensional high-resolution spectrum with information on chemical shifts, relative peak areas, J-coupling constants, and multiplet patterns. In this review, two comprehensive descriptions of an iZQC signal are presented first. The existing iZQC techniques are then systematically described. The details and underlying mechanisms of these techniques are discussed. Finally, the in vivo applications of iZQC spectroscopic techniques are given.