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Intermittent hypoxic loading: a model system to study the early stages of myocardial lesions.

Authors
Type
Published Article
Journal
Acta morphologica Academiae Scientiarum Hungaricae
Publication Date
Volume
25
Issue
4
Pages
279–284
Identifiers
PMID: 617772
Source
Medline

Abstract

Authors applied the model system of intermittent hypoxic loading to study the development of early myocardial alterations. It was found that a primary role is played by the deficiency of high-energy phosphate synthesis and by the disturbance of energetic and transport processes. The change of Ca2+-control, activation of anaerobic glycolysis and intracellular acidosis were found to be instrumental in decreasing contractility, impairing membranes and finally in a diffuse destruction of myofilaments.

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