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Intermittent Access to Ethanol Induces Escalated Alcohol Consumption in Primates

Authors
  • Lindell, S. G.
  • Schwandt, M. L.
  • Suomi, S. J.
  • Rice, K. C.
  • Heilig, Markus
  • Barr, C. S.
Publication Date
Jan 01, 2017
Identifiers
DOI: 10.4172/2324-9005.1000163
OAI: oai:DiVA.org:liu-146056
Source
DiVA - Academic Archive On-line
Keywords
Language
English
License
Unknown
External links

Abstract

Escalation of voluntary alcohol drinking is characteristic of alcohol addiction and can be induced in rodents using intermittent access to alcohol. This model has been used to evaluate candidate therapeutics, but key systems involved in the transition into alcohol addiction, such as CRF, differ in their organization between rodents and primates. We examined the ability of an intermittent access schedule to induce escalation of voluntary alcohol drinking in non-human primates and used this model to assess the role of corticotropin releasing hormone (CRF) signaling in this process.

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