Affordable Access

deepdyve-link
Publisher Website

Interleukins and atherosclerosis: a dysfunctional family grows.

Authors
  • Spears, Larry D1
  • Razani, Babak
  • Semenkovich, Clay F
  • 1 Department of Medicine, Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis, MO 63110, USA.
Type
Published Article
Journal
Cell metabolism
Publication Date
Nov 05, 2013
Volume
18
Issue
5
Pages
614–616
Identifiers
DOI: 10.1016/j.cmet.2013.10.009
PMID: 24206661
Source
Medline
License
Unknown

Abstract

Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.

Report this publication

Statistics

Seen <100 times