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Interleukin-1beta -511T>C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion.

Authors
  • Kim, Jung O1
  • Lee, Woo Sik2
  • Lee, Bo Eun1
  • Jeon, Young Joo1
  • Kim, Young Ran3
  • Jung, Sang Hee3
  • Chang, Sung Woon3
  • Kim, Nam Keun4
  • 1 Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea. , (North Korea)
  • 2 Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, South Korea. , (North Korea)
  • 3 Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea. , (North Korea)
  • 4 Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea. Electronic address: [email protected] , (North Korea)
Type
Published Article
Journal
Fertility and sterility
Publication Date
Jul 01, 2014
Volume
102
Issue
1
Identifiers
DOI: 10.1016/j.fertnstert.2014.03.037
PMID: 24784935
Source
Medline
Keywords
License
Unknown

Abstract

According to these results, IL-1β -511T>C may be a predisposing factor to RPL susceptibility. However, the mechanism underlying the function of IL-1β -511T>C in RPL remains to be determined, and further studies are needed to improve understanding of the roles of IL-1β -511T>C, using a larger and more heterogeneous cohort.

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