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Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice.

Authors
  • Di Castro, Maria Amalia1
  • Garofalo, Stefano1
  • Mormino, Alessandro1
  • Carbonari, Laura1
  • Di Pietro, Erika1
  • De Felice, Eleonora1
  • Catalano, Myriam1
  • Maggi, Laura1
  • Limatola, Cristina2
  • 1 Department of Physiology and Pharmacology, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy. , (Italy)
  • 2 IRCCS Neuromed Via Atinese 18, 86077 Pozzilli, Italy; Department of Physiology and Pharmacology, Sapienza University, Laboratory affiliated to Istituto Pasteur, Italy. Electronic address: [email protected]. , (Italy)
Type
Published Article
Journal
Brain Behavior and Immunity
Publisher
Elsevier
Publication Date
Jan 01, 2024
Volume
115
Pages
652–666
Identifiers
DOI: 10.1016/j.bbi.2023.11.015
PMID: 37992787
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cytokines are potent immunomodulators exerting pleiotropic effects in the central nervous system (CNS). They influence neuronal functions and circuit activities with effects on memory processes and behaviors. Here, we unravel a neuromodulatory activity of interleukin-15 (IL-15) in mouse brain. Acute exposure of hippocampal slices to IL-15 enhances gamma-aminobutyricacid (GABA) release and reduces glutamatergic currents, while chronic treatment with IL-15 increases the frequency of hippocampal miniature inhibitory synaptic transmission and impairs memory formation in the novel object recognition (NOR) test. Moreover, we describe that serotonin is involved in mediating the hippocampal effects of IL-15, because a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and ameliorates mice performance in the NOR test. These findings provide new insights into the modulatory activities of cytokines in the CNS, with implications on behavior. Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

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