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Interleukin-6 and melanoma.

Authors
  • Hoejberg, Lise
  • Bastholt, Lars
  • Schmidt, Henrik
Type
Published Article
Journal
Melanoma Research
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Oct 01, 2012
Volume
22
Issue
5
Pages
327–333
Identifiers
DOI: 10.1097/CMR.0b013e3283543d72
PMID: 22713796
Source
Medline
License
Unknown

Abstract

Interleukin-6 (IL-6) is a pleiotropic immunomodulatory cytokine produced by various types of cells, including melanoma cells. IL-6 plays a major role in the pathogenesis and development of malignancies. It promotes tumour growth by inhibition of apoptosis and induces tumour angiogenesis. IL-6 is deregulated in many types of cancers, and increased serum concentration of IL-6 has been correlated with a worse prognosis in patients with different cancers, including melanoma. Several serum cytokines including IL-6 play an important role in the development and progression of melanoma; however, the specific biological functions of IL-6 in progression of melanoma are unknown. In this review, we present studies on cell cultures and mouse models and summarize published clinical studies on IL-6 and melanoma.

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