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Interleukin-4 receptor expression by human B cells: functional analysis with a human interleukin-4 toxin, DAB389IL-4.

Authors
  • Jabara, H H
  • Vercelli, D
  • Schneider, L C
  • Williams, D P
  • Genbauffe, F S
  • Poisson, L R
  • Waters, C A
  • Geha, R S
Type
Published Article
Journal
Journal of Allergy and Clinical Immunology
Publisher
Elsevier
Publication Date
Apr 01, 1995
Volume
95
Issue
4
Pages
893–900
Identifiers
PMID: 7722171
Source
Medline
License
Unknown

Abstract

IgE-secreting B cells no longer express functional IL-4R. Therapies for allergic disease that target the IL-4R would not affect IgE-secreting B cells but may block the recruitment of B cells into the IgE-secreting pool. For optimal benefits this approach may be combined with therapies that target IL-4R-, IgE-secreting B cells.

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