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Interleukin-3 induces translocation and down-regulation of protein kinase C in human platelets.

Authors
  • Cook, P P
  • Chen, J
  • Ways, D K
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Jun 15, 1992
Volume
185
Issue
2
Pages
670–675
Identifiers
PMID: 1610359
Source
Medline
License
Unknown

Abstract

Protein kinase C (PKC) is a family of phospholipid-dependent kinases that is involved, along with calcium mobilization, in the activation of human platelets. Since interleukin-3 (IL-3) has been shown to act, in part, by activating PKC, we investigated the effect of IL-3 on PKC activity and content in human platelets. Exposure of platelets to 10 ng/ml of IL-3 was associated with a rapid (i.e., within 3 minutes) translocation of PKC activity and content from the cytosol to the membrane fraction. In addition, treatment with IL-3 effected a time-dependent down-regulation of PKC activity and content. We speculate that IL-3 may act as a modulator of PKC-dependent pathways in the human platelet.

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