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Interleukin 1beta induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection.

Authors
  • Gööz, M
  • Shaker, M
  • Gööz, P
  • Smolka, A J
Type
Published Article
Journal
Gut
Publication Date
Sep 01, 2003
Volume
52
Issue
9
Pages
1250–1256
Identifiers
PMID: 12912854
Source
Medline
License
Unknown

Abstract

We conclude that IL-1beta induces gastric epithelial cell MMP-3 secretion, contributing to epithelial tissue destruction during H pylori infection. However, other bacterial/host factors are needed to mediate the full gastric epithelial cell MMP-3 secretory response induced by H pylori infection.

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