Interleukin-10 secretion from CD14+ peripheral blood mononuclear cells is downregulated in patients with acne vulgaris.
- Authors
- Type
- Published Article
- Journal
- British Journal of Dermatology
- Publisher
- Wiley (Blackwell Publishing)
- Publication Date
- Feb 01, 2010
- Volume
- 162
- Issue
- 2
- Pages
- 296–303
- Identifiers
- DOI: 10.1111/j.1365-2133.2009.09420.x
- PMID: 19796181
- Source
- Medline
- License
- Unknown
Abstract
These data suggest that patients with acne have a proinflammatory cytokine milieu and crucially are unable to contain early inflammatory changes due to a specific defect in immunosurveillance, namely low monocyte IL-10 production. Our observations raise the possibility that acne therapeutics might profitably target IL-10 both as a regulator of proinflammatory cytokines and in augmenting the CD14+ cell phagocytic response.
