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Interleukin-10 secretion from CD14+ peripheral blood mononuclear cells is downregulated in patients with acne vulgaris.

Authors
  • Caillon, F
  • O'Connell, M
  • Eady, E A
  • Jenkins, G R
  • Cove, J H
  • Layton, A M
  • Mountford, A P
Type
Published Article
Journal
British Journal of Dermatology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 01, 2010
Volume
162
Issue
2
Pages
296–303
Identifiers
DOI: 10.1111/j.1365-2133.2009.09420.x
PMID: 19796181
Source
Medline
License
Unknown

Abstract

These data suggest that patients with acne have a proinflammatory cytokine milieu and crucially are unable to contain early inflammatory changes due to a specific defect in immunosurveillance, namely low monocyte IL-10 production. Our observations raise the possibility that acne therapeutics might profitably target IL-10 both as a regulator of proinflammatory cytokines and in augmenting the CD14+ cell phagocytic response.

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