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Interleukin 1 system and sex steroid receptor expression in human breast cancer: interleukin 1alpha protein secretion is correlated with malignant phenotype.

Authors
  • Singer, Christian F
  • Kronsteiner, Nicole
  • Hudelist, Gernot
  • Marton, Erika
  • Walter, Ingrid
  • Kubista, Marion
  • Czerwenka, Klaus
  • Schreiber, Martin
  • Seifert, Michael
  • Kubista, Ernst
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Oct 15, 2003
Volume
9
Issue
13
Pages
4877–4883
Identifiers
PMID: 14581361
Source
Medline
License
Unknown

Abstract

We have demonstrated the presence of a functional IL-1 system in breast cancer and found that IL-1alpha is inversely correlated with local sex steroid receptor expression. We hypothesize that the unphysiological expression of IL-1alpha in less differentiated and ERalpha-negative tumors might contribute to their local invasiveness and malignant behavior.

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