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Interferon-inhibited human osteosarcoma xenografts induce host bone in nude mice.

Authors
  • Forster, S
  • Triffitt, J T
  • Bauer, H C
  • Brosjö, O
  • Nilsson, O S
  • Smith, R
  • Sykes, B
Type
Published Article
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Publication Date
Apr 01, 1988
Volume
3
Issue
2
Pages
199–202
Identifiers
PMID: 3213616
Source
Medline
License
Unknown

Abstract

The growth of human osteosarcoma xenografts in nude mice can be inhibited by human interferon-alpha (IFN-alpha). Histologic examination of growth-inhibited tumors has revealed mineralization and partial replacement of the tumor by normal bone tissue. We have investigated whether the normal bone tissue was formed by differentiated tumor cells or by induction of host stroma to differentiate into bone tissue. Employing antibodies to both murine and human type I collagen, it was found that the normal bone produced in IFN-inhibited osteosarcomas was host derived. These results suggest that IFN induced the osteosarcoma cells to produce a bone-inductive agent that interacts with the host cells, and leads to the formation of mature normal bone tissue in a heterotopic site.

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