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Interferon-inducing characteristics of MM virus.

Authors
  • Giron, D J
  • Allen, P T
  • Pindak, F F
  • Schmidt, J P
Type
Published Article
Journal
Applied microbiology
Publication Date
Mar 01, 1971
Volume
21
Issue
3
Pages
387–393
Identifiers
PMID: 4324191
Source
Medline
License
Unknown

Abstract

Interferon induction by MM virus in mice and in L cells was studied. In mice the virus readily induced interferon. The time of appearance was dose-dependent. A large virus dose induced interferon by 4 hr, whereas a small dose resulted in interferon production which paralleled virus replication 24 hr after infection. In L cells the interferon-inducing capacity of the virus was rapidly destroyed by ultraviolet light irradiation. Heating (56 C) of the virus, on the other hand, greatly increased its ability to induce interferon. Interferon production could also be increased by prior treatment of the cells with homologous interferon (priming). The increase in interferon production after priming was dependent on the concentration of interferon used for priming, the length of interferon treatment, and the multiplicity of infection. It is suggested that MM virus might be useful for the further study of the mechanisms involved in the production and action of interferon.

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