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Interferon-gamma responses to Plasmodium falciparum liver-stage antigen-1 and merozoite-surface protein-1 increase with age in children in a malaria holoendemic area of western Kenya

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BioMed Central
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PMC
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  • Research
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  • Biology

Abstract

1475-2875-2-37.fm ral ss BioMed CentMalaria Journal Open AcceResearch Interferon-gamma responses to Plasmodium falciparum liver-stage antigen-1 and merozoite-surface protein-1 increase with age in children in a malaria holoendemic area of western Kenya Kiprotich Chelimo1,2, Peter O Sumba2, James W Kazura3, Ayub V Ofula1 and Chandy C John*3,4 Address: 1Maseno University, P.O Box 333, Maseno, Kenya, 2Kenya Medical Research Institute, P.O Box, 1578, Kisumu, Kenya, 3Center for Global Health and Disease, Case Western Reserve University and Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA and 4Rainbow Center for International Child Health and Division of Pediatric Infectious Diseases, Case Western Reserve University and Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA Email: Kiprotich Chelimo - kchelimo@kisian.mimcom.net; Peter O Sumba - odadakasumba@yahoo.com; James W Kazura - jxk14@cwru.edu; Ayub V Ofula - ofullavo@yahoo.com; Chandy C John* - ccj@cwru.edu * Corresponding author Abstract Background: In areas of high-level, year-round malaria transmission, morbidity and mortality due to malaria decrease after the first two to three years of life. This reduction may be related to the development of cellular immunity to specific antigens expressed in the different life-cycle stages of Plasmodium falciparum. Methods: A cross sectional study was conducted to evaluate T cell cytokine responses to the P. falciparum pre-erythrocytic antigen liver-stage antigen-1 (LSA-1) and the blood-stage antigen merozoite-surface protein-1 (MSP-1) in children under five years of age residing in a malaria holoendemic region of western Kenya. Interferon-γ (IFN-γ) and interleukin-10 (IL-10) responses to the LSA-1 T3 peptide (aa 1813–1835) and the MSP-1 aa20–39 peptide were tested in 48 children. Results: The proportion of children producing IFN-γ to LSA-1 and to MSP-1 increased with age: in the 0–12, 13–24, 25–36 and 37–48 month age groups, zero, 11.1, 36.4 and 40% of c

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