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Interferon-gamma: a key immunoregulatory lymphokine.

Authors
  • Williams, J G
  • Jurkovich, G J
  • Maier, R V
Type
Published Article
Journal
The Journal of surgical research
Publication Date
Jan 01, 1993
Volume
54
Issue
1
Pages
79–93
Identifiers
PMID: 8429643
Source
Medline
License
Unknown

Abstract

Interferon-gamma is an important component of numerous host responses to inflammatory insults. Data from in vitro and animal studies suggest that this agent may have clinical uses in immunocompromised patients who are at increased risk for infectious complications. In addition to reviewing our current understanding of the in vitro and in vivo actions of interferon-gamma, this article cautions that the potential for adverse reactions exists when interferon-gamma is administered to an immunologically competent host.

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