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Intercomparison of inductively coupled plasma mass spectrometry, quantitative neutron capture radiography, and prompt gamma activation analysis for the determination of boron in biological samples.

Authors
  • Schütz, C L1
  • Brochhausen, C
  • Hampel, G
  • Iffland, D
  • Kuczewski, B
  • Otto, G
  • Schmitz, T
  • Stieghorst, C
  • Kratz, J V
  • 1 Institute for Nuclear Chemistry, University of Mainz, Mainz, Germany. [email protected] , (Germany)
Type
Published Article
Journal
Analytical and Bioanalytical Chemistry
Publisher
Springer-Verlag
Publication Date
Oct 01, 2012
Volume
404
Issue
6-7
Pages
1887–1895
Identifiers
DOI: 10.1007/s00216-012-6329-4
PMID: 22918535
Source
Medline
License
Unknown

Abstract

Boron determination in blood and tissue samples is a crucial task especially for treatment planning, preclinical research, and clinical application of boron neutron capture therapy (BNCT). Comparison of clinical findings remains difficult due to a variety of analytical methods, protocols, and standard reference materials in use. This paper addresses the comparability of inductively coupled plasma mass spectrometry, quantitative neutron capture radiography, and prompt gamma activation analysis for the determination of boron in biological samples. It was possible to demonstrate that three different methods relying on three different principles of sample preparation and boron detection can be validated against each other and yield consistent results for both blood and tissue samples. The samples were obtained during a clinical study for the application of BNCT for liver malignancies and therefore represent a realistic situation for boron analysis.

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