Affordable Access

deepdyve-link
Publisher Website

Intercellular crosstalk of hepatic stellate cells in liver fibrosis: New insights into therapy.

Authors
  • Cai, Xuanyan1
  • Wang, Jiajia1
  • Wang, Jincheng1
  • Zhou, Qian2
  • Yang, Bo1
  • He, Qiaojun3
  • Weng, Qinjie4
  • 1 Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China. , (China)
  • 2 Department of Pharmacy, Hangzhou Medical College, Hangzhou 310053, PR China. , (China)
  • 3 Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China; Center for Drug Safety Evaluation and Research, Zhejiang University, Hangzhou 310058, PR China. , (China)
  • 4 Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China; Center for Drug Safety Evaluation and Research, Zhejiang University, Hangzhou 310058, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Pharmacological Research
Publisher
Elsevier
Publication Date
Feb 21, 2020
Volume
155
Pages
104720–104720
Identifiers
DOI: 10.1016/j.phrs.2020.104720
PMID: 32092405
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to date. Activated hepatic stellate cells (HSCs) are the major cellular source of matrix-producing myofibroblasts, playing a central role in the initiation and progression of liver fibrosis. Paracrine signals from resident and inflammatory cells such as hepatocytes, liver sinusoidal endothelial cells, hepatic macrophages, natural killer/natural killer T cells, biliary epithelial cells, hepatic progenitor cells, and platelets can directly or indirectly regulate HSC differentiation and activation. Intercellular crosstalk between HSCs and those "responded" cells has been a critical event involved in HSC activation and fibrogenesis. This review summarizes recent advancement regarding intercellular communication between HSCs and other "responded cells" during liver fibrosis and experimental models of intercellular crosstalk systems, and provides novel ideas for potential antifibrotic therapeutic strategy. Copyright © 2020 Elsevier Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times