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Intercalation of tetracationic metalloporphyrins and related compounds into DNA.

Authors
  • Dougherty, G
Type
Published Article
Journal
Journal of Inorganic Biochemistry
Publisher
Elsevier
Publication Date
Oct 01, 1988
Volume
34
Issue
2
Pages
95–103
Identifiers
PMID: 2848930
Source
Medline
License
Unknown

Abstract

Electron paramagnetic resonance (e.p.r.) studies of thin DNA-chelate films indicate that both the water soluble planar macrocyclic chelates, cobalt (II) tetra (2,3-N-methylpyridinium) porphyrazine (cobalt (II) TMTPPA), and vanadyl (II) 5,10,15,20-tetra-(4-methylpyridinium) porphyrin (Vo (II) TMTPyP) can bind to calf thymus DNA intercalatively. The intercalation of cobalt (II) porphyrazine is in contrast to the binding of cobalt (II) porphyrin, which is known to bind nonintercalatively. Five-coordinate cobalt (II) porphyrazine is sufficiently slim, even with its single out-of-plane ligand, to permit significant intercalative binding. Vanadyl (II) porphyrin intercalates into calf thymus DNA, but not as readily as cobalt (II) porphyrazine.

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