Interactions of phosphodiester and phosphorothioate oligonucleotides with intestinal epithelial Caco-2 cells.
- Published Article
- Publication Date
Jul 01, 1996
Binding to surface proteins seems a major pathway for binding and internalization for both oligonucleotide chemistries and appear consistent with receptor (binding protein)-mediated endocytosis. Whether this binding protein-mediated entry of oligonucleotides can result in efficient transepithelial transport, however, requires further study.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/8842040