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Interactions of phosphodiester and phosphorothioate oligonucleotides with intestinal epithelial Caco-2 cells.

Authors
  • Beck, G F
  • Irwin, W J
  • Nicklin, P L
  • Akhtar, S
Type
Published Article
Journal
Pharmaceutical research
Publication Date
Jul 01, 1996
Volume
13
Issue
7
Pages
1028–1037
Identifiers
PMID: 8842040
Source
Medline
License
Unknown

Abstract

Binding to surface proteins seems a major pathway for binding and internalization for both oligonucleotide chemistries and appear consistent with receptor (binding protein)-mediated endocytosis. Whether this binding protein-mediated entry of oligonucleotides can result in efficient transepithelial transport, however, requires further study.

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