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Interactions of drugs with the developing kidney.

Authors
  • Blowey, D L
  • Ben-David, S
  • Koren, G
Type
Published Article
Journal
Pediatric clinics of North America
Publication Date
Dec 01, 1995
Volume
42
Issue
6
Pages
1415–1431
Identifiers
PMID: 8614593
Source
Medline
License
Unknown

Abstract

Interactions between drugs and the kidney are necessary for renal drug elimination, metabolism, and occasionally for therapeutic effect. These interactions may result also in renal toxicity. Understanding the kidney's role in drug-handling helps the clinician to be aware of potential drug interactions and toxicity. Drug disposition, elimination, and toxicity may differ with development and are to be considered when prescribing drugs for children. Nephrotoxicity associated with drugs, although common, is usually reversible with discontinuation of the drug; however, when drug therapy with a well-known nephrotoxic drug (e.g., cisplatin) is necessary, pharmacologic modulators may play a role in limiting the associated nephrotoxicity.

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